Colorectal Cancer Prevention

The natural FOS content in Yaconz yacon syrup are able to escape enzymatic digestion in the upper gastrointestinal tract. They can reach the colon intact where microbial fermentation takes place. The intake of natural FOS stimulates the proliferation of bifidobacteria, a group of beneficial bacteria naturally found in the human colon.

Short-chain fatty acids (SCFA), the endproducts of FOS fermentation by the intestinal microbiota, can also favour the growth of health-promoting bacteria such as Bifidobacterium spp. and Lactobacillus spp., while reducing or maintaining pathogenic populations such as Clostridium spp. and Escherichia coli at low levels.

Recent studies show that

SCFA can suppress inflammation and cancer by increasing local immune response, decreasing colon pH and promoting ammonia and amine excretion.

During carcinogenesis, SCFA production in the colon by beneficial bacteria decreases cellular proliferation and induces apoptosis, especially in colon tumour cells. In fact, increasing butyrate production has also been shown to decrease the development of preneoplastic aberrant crypt foci lesions and delay tumour progression.

References
  • Caetano, B. F., de Moura, N. A., Almeida, A. P., Dias, M. C., Sivieri, K., & Barbisan, L. F. (2016). Yacon (Smallanthus sonchifolius) as a food supplement: health-promoting benefits of fructooligosaccharides. Nutrients, 8(7), 436.
  • Canfora, E. E., Jocken, J. W., & Blaak, E. E. (2015). Short-chain fatty acids in control of body weight and insulin sensitivity. Nature Reviews Endocrinology, 11(10), 577.
  • Genta, S., Cabrera, W., Habib, N., Pons, J., Carillo, I. M., Grau, A., & Sánchez, S. (2009). Yacon syrup: beneficial effects on obesity and insulin resistance in humans. Clinical Nutrition, 28(2), 182-187.